Soothing music for two opened by lush chords at the beginning (6)
I believe the answer is:
dulcet
'soothing' is the definition.
(synonyms)
'music for two opened by lush chords at the beginning' is the wordplay.
'music for two' becomes 'duet' (I've seen this before).
'opened by' is an insertion indicator (one word creates an opening in another word).
'at the beginning' says to take the initial letters.
The first letters of 'lush chords' is 'lc'.
'duet' going around 'lc' is 'DULCET'.
(Other definitions for dulcet that I've seen before include "Sweet-sounding, melodious" , "Sweet on the ear" , "Mellifluous, pleasant to the ear" , "Mellifluous, pleasing to the ear" , "Sounding sweet, mellifluous" .)