Sophisticated city, European (6)
I believe the answer is:
urbane
'sophisticated' is the definition.
('urbane' can be a synonym of 'sophisticated')
'city european' is the wordplay.
'city' becomes 'ur'.
'european' becomes 'bane' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'ur'+'bane'='URBANE'
Can you help me to learn more?
(Other definitions for urbane that I've seen before include "Smooth-mannered" , "Polished -- sophisticated" , "Cultured" , "Unbare, being suave." , "Suave, refined, courteous" .)