Sort of rise within my depression (6)
I believe the answer is:
misery
'depression' is the definition.
(thesaurus)
'sort of rise within my' is the wordplay.
'sort of' indicates anagramming the letters.
'within' means one lot of letters goes inside another.
'rise' is an anagram of 'iser'.
'iser' put within 'my' is 'MISERY'.
(Other definitions for misery that I've seen before include "Intense unhappiness" , "Great suffering" , "Party-pooper" , "Feeling of great unhappiness" , "Extreme unhappiness" .)