Sound the organ made (5)
I believe the answer is:
groan
'sound' is the definition.
(I have seen 'Sound of despair ' mean 'groan' so perhaps 'sound' could also mean 'groan')
'organ made' is the wordplay.
'made' indicates an anagram.
'organ' anagrammed gives 'GROAN'.
'the' is the link.
(Other definitions for groan that I've seen before include "See 18 Down" , "Express disappointment, pain" , "Sound of pain or disapproval" , "Sound pained; Gormenghast earldom" , "Make pained sound" .)