South American bloke at home in most of district (9)
I believe the answer is:
argentine
'south american' is the definition.
(I've seen this before)
'bloke at home in most of district' is the wordplay.
'bloke' becomes 'gent' (I've seen this in other clues**).
'at home' becomes 'in' ('in' can be similar in meaning to 'at home').
'in' means one lot of letters goes inside another.
'most of' means to remove the last letter.
'district' becomes 'area' (I've seen this before).
'gent'+'in'='gentin'
'area' with its final letter removed is 'are'.
'gentin' inserted inside 'are' is 'ARGENTINE'.
(Other definitions for argentine that I've seen before include "silvery" , "El Papa is one" , "like silver" , "from South America" , "fish" .)