Spanish painter born in Crete in 1541 (2,5)
I believe the answer is:
el greco
(Other definitions for el greco that I've seen before include "Famous painter's nickname" , "Cretan-born Spanish painter, d. 1614" , "Sixteenth to seventeenth century Greek-born Spanish painter" , "Sp. painter, born Domen- ikos Theotokopoulos" , "Greek born Spanish painter" .)