Crossword Genius

Sparkling Italian wine, or the region it comes from (4)

Ross

I believe the answer is:

asti

(Other definitions for asti that I've seen before include "Sparkling wine named after an Italian Piedmont town" , "White wine named after a town in Piedmont" , "Bubbly wine" , "Fizzy wine" , "Italian town, famous for its wine" .)

I've seen this clue in The New York Times.
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