Speak up for the man upstairs on the radio in game (4)
I believe the answer is:
prey
'game' is the definition.
(thesaurus)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for prey that I've seen before include "Quarry, target" , "Hunter's quarry" , "Quarry, fair game" , "Animal hunted by another for food" , "Victim, quarry" .)