Specially, but in only one way (8)
I believe the answer is:
uniquely
'specially but in' is the definition.
Both the answer and definition are adverbs. Perhaps there's an association between them I don't understand?
'only one way' is the wordplay.
'only' becomes 'unique' (synonyms).
'one way' becomes 'ly' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'unique'+'ly'='UNIQUELY'
Can you help me to learn more?
(Another definition for uniquely that I've seen is " In unprecedented fashion".)