Speculative work discussed a couple of hypothetical variants; ... (3-2)
I believe the answer is:
sci-fi
'speculative work' is the definition.
The definition suggests a singular noun which matches the answer.
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for sci-fi that I've seen before include "Space fiction" , "Literary genre (abbrev)" , "Fantasy genre based in the future" , "Space opera genre" , "Sort of book" .)