Spice Girls' opening after enthusiastic follower makes makes entrance, initially (6)
I believe the answer is:
nutmeg
'spice' is the definition.
(I know that Nutmeg is a spice)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for nutmeg that I've seen before include "Spicy seasoning - hard fruit for little Margaret?" , "Kick the football between an opponent's legs" , "Kernel and girl for a spice" , "(In soccer) kick the ball between an opponent's legs" , "Give out light" .)