Spider-Man's skin layer (5)
I believe the answer is:
derma
'skin layer' is the definition.
(the derma or dermis is a layer of the skin)
'spider-man's' is the wordplay.
'DERMA' is hidden in amongst the letters.
However, I'm not sure how this is indicated.
Can you help me to learn more?
(Other definitions for derma that I've seen before include "Second protective layer" , "Corium, the inner layer of skin" , "Deep vascular inner layer of the skin" , "Layer of living skin below the surface" , "Flesh" .)