Spike prankster's drink (6)
I believe the answer is:
impale
'spike' is the definition.
(synonyms)
'prankster's drink' is the wordplay.
'prankster' becomes 'imp'.
'drink' becomes 'ale' (ale is a kind of drink).
'imp'+'ale'='IMPALE'
(Other definitions for impale that I've seen before include "Kill by piercing with a sharp stake" , "Fix as on a sharp stick" , "Transfix with spear" , "Pierce, me pail (anag.)" , "go through with it" .)