Spirit bar winos regularly ignored (4)
I believe the answer is:
brio
'spirit' is the definition.
(thesaurus)
'bar winos regularly ignored' is the wordplay.
'regularly ignored' means one should take alternating letters.
'bar'+'winos'='barwinos'
The alternate letters of 'barwinos' are 'BRIO'.
(Other definitions for brio that I've seen before include "'Liveliness, vivacity (4)'" , "Vivacity - spirit" , "Animation (Italian)" , "Spiritedness" , "Drive" .)