Spirit can go mad, getting cold (6)
I believe the answer is:
cognac
'spirit' is the definition.
(I know that Cognac is a type of spirit)
'can go mad getting cold' is the wordplay.
'mad' indicates anagramming the letters.
'getting' means one lot of letters goes inside another.
'cold' becomes 'c' (eg on taps).
'can'+'go'='cango'
'cango' anagrammed gives 'ognac'.
'ognac' going around 'c' is 'COGNAC'.
(Other definitions for cognac that I've seen before include "Brandy as for Napoleon (6)." , "French brandy region" , "Brandy of the French Charente" , "Liquor" , "(French district famed for) fine brandy" .)