Spite enraged camel round island (6)
I believe the answer is:
malice
'spite' is the definition.
(synonyms)
'enraged camel round island' is the wordplay.
'enraged' indicates an anagram.
'round' is an insertion indicator.
'island' becomes 'i'.
'camel' with letters rearranged gives 'malce'.
'malce' enclosing 'i' is 'MALICE'.
(Other definitions for malice that I've seen before include "evil intent" , "Hatred" , "Ill will, a desire to harm others" , "Bitterness" , "Hate" .)