Spiteful woman to abandon wrongdoing (3-5)
I believe the answer is:
she-devil
'spiteful woman' is the definition.
(I've seen this before)
'abandon wrongdoing' is the subsidiary indication.
'abandon' becomes 'shed' (I've seen this before).
'wrongdoing' becomes 'evil' (evil is a kind of wrongdoing).
'shed'+'evil'='shedevil'
'to' is the link.
(Other definitions for she-devil that I've seen before include "woman like Lilith" , "Malicious and spiteful woman" .)