Spoil 1 + 1,000 + 2? (6)
I believe the answer is:
impair
'spoil' is the definition.
(I know that spoil can be written as impair)
'1 1000 2?' is the wordplay.
'1' becomes 'I' (Roman numeral).
'1000' becomes 'M' (roman numeral).
'2?' becomes 'pair' (pair is a kind of 2).
'i'+'m'+'pair'='IMPAIR'
(Other definitions for impair that I've seen before include "Courteous man (colloq.)" , "Cause weakening of, damage" , "Harm" , "Damage or handicap" , "Hurt or handicap" .)