Spoil a drink (6)
I believe the answer is:
scotch
I believe this clue is a double definition.
'spoil' is the first definition.
(synonyms)
'a drink' is the second definition.
(Scotch is an example)
(Other definitions for scotch that I've seen before include "dish" , "Finish off" , "Put an end to - in Glasgow? (6)" , "Frustrate; quash" , "Whisky (not whiskey!)" .)