Spoil jog around Italy (4)
I believe the answer is:
ruin
'spoil' is the definition.
(ruining is a kind of spoiling)
'jog around italy' is the wordplay.
'jog' becomes 'run' (I've seen this before).
'around' means one lot of letters goes inside another.
'italy' becomes 'i'.
'run' enclosing 'i' is 'RUIN'.
(Other definitions for ruin that I've seen before include "building now demolished" , "Irreparably damage" , "Complete collapse or destruction" , "Wrecked building" , "Physical collapse" .)