Spook a transposition of respect (7)
I believe the answer is:
spectre
'spook' is the definition.
(both can mean a ghost)
'a transposition of respect' is the wordplay.
'a transposition of' indicates an anagram (I've seen 'transposition' mean this).
'respect' with letters rearranged gives 'SPECTRE'.
(Other definitions for spectre that I've seen before include "something seen as a threat" , "'Phantom, shade (7)'" , "Wraith" , "Enemy organisation for James Bond; ghost" , "spirit" .)