Spookiest retirees heading off delirium (7)
I believe the answer is:
eeriest
'spookiest' is the definition.
('eery' can be a synonym of 'spooky')
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for eeriest that I've seen before include "Most ghostly" , "Weirdest, I.e., trees are wierd" , "Most weird" , "Most strange and frightening" , "Strangest" .)