Spooky condition is serene, somehow (8)
I believe the answer is:
eeriness
'spooky condition' is the definition.
'is serene somehow' is the wordplay.
'somehow' indicates anagramming the letters.
'is'+'serene'='isserene'
'isserene' with letters rearranged gives 'EERINESS'.
(Other definitions for eeriness that I've seen before include "Ghostly atmosphere" , "Weird quality" , "'Ghostliness, scariness (8)'" , "Ghostly quality" , "Horror movie featuring such" .)