Spot intrigue in school (7)
I believe the answer is:
splotch
'spot' is the definition.
(I know that splotch is a type of spot)
'intrigue in school' is the wordplay.
'intrigue' becomes 'plot' (I've seen this before).
'in' means one lot of letters goes inside another.
'school' becomes 'sch' (abbreviation).
'plot' going into 'sch' is 'SPLOTCH'.
(Other definitions for splotch that I've seen before include "Spot, splash, smear" , "Mark" .)