Spots long tie being knotted (7)
I believe the answer is:
lentigo
'spots' is the definition.
(I've seen this before)
'long tie being knotted' is the wordplay.
'being knotted' indicates an anagram.
'long'+'tie'='longtie'
'longtie' is an anagram of 'LENTIGO'.
(Other definitions for lentigo that I've seen before include "Spots" , "skin discoloration" , "Technical name for a freckle" , "Skin disease" , "Spot" .)