Spots men carting bottles up (4)
I believe the answer is:
acne
'spots' is the definition.
(I've seen this before)
'men carting bottles up' is the wordplay.
'bottles' indicates a hidden word (bottling is a kind of containing).
'up' says the letters should be written in reverse (in down clue: letters go upwards).
'enca' can be found hidden inside 'men carting'.
'enca' back-to-front is 'ACNE'.
(Other definitions for acne that I've seen before include "Problem to face in" , "Skin condition prevalent among teenagers" , "Adolescent spots" , "Skin disorder" , "Teenage spots" .)