Spots regularly ascended (4)
I believe the answer is:
acne
'spots' is the definition.
(I've seen this before)
'regularly ascended' is the wordplay.
'regularly' indicates alternate letters (regularly take one letter, leave next etc.).
The alternate letters of 'ascended' are 'ACNE'.
(Other definitions for acne that I've seen before include "Skin rash" , "sort of disease" , "Skin problem, mainly of teenagers" , "Teenage spots" , "Facial spots" .)