Spots starting around chin, nose, eyes (4)
I believe the answer is:
acne
'spots' is the definition.
(I've seen this before)
'starting around chin nose eyes' is the wordplay.
'starting' suggests taking the first letters.
The initial letters of 'around chin nose eyes' is 'ACNE'.
(Other definitions for acne that I've seen before include "Spotty coverage" , "Pimply ailment of adolescnce" , "Problem to face in" , "(Inflammation causing) spots" , "Inflammation of glands in skin" .)