Stands up to ugly sisters (7)
I believe the answer is:
resists
'stands up to' is the definition.
(I've seen this before)
'ugly sisters' is the wordplay.
'ugly' is an anagram indicator (an ugly or wrong form of the letters).
'sisters' anagrammed gives 'RESISTS'.
(Other definitions for resists that I've seen before include "Fights back" , "Opposes, puts up fight" , "Defies" , "Is hostile to" , "Tries to stop" .)