Star last to depart Sin City (4)
I believe the answer is:
vega
'star' is the definition.
(star in the constellation Lyra)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for vega that I've seen before include "Bright star of constellation Lyra" , "Fifth brightest star" , "First magnitude star" , "heavenly body" , "Gave turn to a star" .)