Start a journey with a porter out East (3,3)
I believe the answer is:
set out
'start a journey' is the definition.
(I've seen this before)
'porter out east' is the wordplay.
'porter' becomes 'stout' (porter can mean stout).
'out' is an insertion indicator.
'east' becomes 'e' (abbreviation).
'stout' enclosing 'e' is 'SET-OUT'.
'with a' acts as a link.
(Other definitions for set out that I've seen before include "Begin a journey or declare" , "Begin a journey or arrange display" , "Depart" , "Start journey, get going" , "Embark (on journey)" .)