Start a journey with a porter out East (3,3)
I believe the answer is:
set out
'start a journey' is the definition.
(I've seen this before)
'a porter out east' is the wordplay.
'a porter' becomes 'stout' ('stout' can be a synonym of 'porter').
'out' means one lot of letters goes inside another.
'east' becomes 'e' ('E' can be a synonym of 'east').
'stout' enclosing 'e' is 'SET-OUT'.
'with' acts as a link.
(Other definitions for set out that I've seen before include "Begin a journey or declare" , "Begin a journey or arrange display" , "Depart" , "Start journey, get going" , "Embark (on journey)" .)