Start again and take for granted pressure is off (6)
I believe the answer is:
resume
'start again' is the definition.
(resume can mean to start doing something again)
'take for granted pressure is off' is the wordplay.
'take for granted' becomes 'presume' (to take for granted as true).
'pressure' becomes 'p' (abbreviation).
'is off' is a deletion indicator.
'presume' with 'p' removed is 'RESUME'.
'and' acts as a link.
(Other definitions for resume that I've seen before include "Go on after a pause" , "Continue - summary" , "Short descriptive summary" , "Begin activity again" , "Pick up again" .)