Start to tour America taking in large city (5)
I believe the answer is:
tulsa
'city' is the definition.
(Tulsa is an example)
'start to tour america taking in large' is the wordplay.
'start to' suggests taking the first letters.
'america' becomes 'usa' ('U.S.A.' can be a synonym of 'america'**).
'taking in' indicates putting letters inside.
'large' becomes 'l'.
The initial letter of 'tour' is 't'.
'usa' enclosing 'l' is 'ulsa'.
't'+'ulsa'='TULSA'
(Other definitions for tulsa that I've seen before include "City in Oklahoma featured in a 60s song" , "Major oil centre" , "Oklahoma river port" , "Where in the States" , "part of Oklahoma" .)