Start up again in Scottish town father abandoned (5)
I believe the answer is:
renew
'start up again' is the definition.
(I've seen this in another clue)
'scottish town father abandoned' is the wordplay.
'scottish town' becomes 'Renfrew' (Renfrew is a town in Scotland).
'father' becomes 'fr' (abbreviation as in a priest's title).
'abandoned' suggests deleting specific letters.
'renfrew' with 'fr' taken out is 'RENEW'.
'in' is the link.
(Other definitions for renew that I've seen before include "Give fresh strength to" , "Begin again" , "Take up again" , "Regenerate" , "what regeneration will do" .)