State of irritation? Blow! (4)
I believe the answer is:
huff
I believe this is a double definition.
'state of irritation?' is the first definition.
'blow' is the second definition.
(huffing is a kind of blowing)
(Other definitions for huff that I've seen before include "Pique - remove from board" , "State of having taken offence" , "Sulky fit" , "Fit of annoyance or ineffectual bluster" , "Passing mood of anger" .)