State of uproar in duma, so he agitated (8)
I believe the answer is:
madhouse
'state of uproar' is the definition.
(I've seen this before)
'duma so he agitated' is the wordplay.
'agitated' is an anagram indicator.
'duma'+'so'+'he'='dumasohe'
'dumasohe' with letters rearranged gives 'MADHOUSE'.
'in' acts as a link.
(Other definitions for madhouse that I've seen before include "State of uproar and total confusion" , "pandemonium?" , "badly run establishment?" , "9d 21d [BEDLAM]" , "asylum" .)