State of Virginia invading Middle Eastern port from the south (6)
I believe the answer is:
nevada
'state' is the definition.
(I know that Nevada is a state)
'virginia invading middle eastern port from the south' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'invading' indicates putting letters inside.
'middle eastern port' becomes 'aden' (I've seen this in another clue).
'from the south' is a reversal indicator (in a down clue, letters go up).
'aden' backwards is 'neda'.
'va' put into 'neda' is 'NEVADA'.
'of' acts as a link.
(Other definitions for nevada that I've seen before include "Sagebrush State" , "The Silver State" , "part of US" , "US state, NV" , "State including Las Vegas" .)