Stink pair of females at home raised (4)
I believe the answer is:
niff
'stink' is the definition.
(I know that niff is a type of stink)
'pair of females at home raised' is the wordplay.
'pair of females' becomes 'FF' (the abbreviation for female repeated).
'at' means one lot of letters go next to another (I've seen this in other clues).
'home' becomes 'in' ('he's home' can mean 'he's in').
'raised' shows that the letters should be reversed in order (going up in a down clue).
'in' in reverse letter order is 'ni'.
'ff' put after 'ni' is 'NIFF'.
(Other definitions for niff that I've seen before include "a stink" , "Hum" .)