Stitching up wound ruins gut (8)
I believe the answer is:
suturing
'stitching up' is the definition.
'suturing' can be an answer for 'stitching' (I have seen 'Surgical stitching ' mean 'suturing' so perhaps 'stitching' could also mean 'suturing'). I'm not certain of the 'up' bit.
'wound ruins gut' is the wordplay.
'wound' is an anagram indicator (wound can mean twisted or turned around).
'ruins'+'gut'='ruinsgut'
'ruinsgut' anagrammed gives 'SUTURING'.
Can you help me to learn more?
(Another definition for suturing that I've seen is " Surgical stitching".)