Stop hiding South American neglect (6)
I believe the answer is:
disuse
'neglect' is the definition.
(I've seen this before)
'stop hiding south american' is the wordplay.
'stop' becomes 'die' (I've seen this in other clues**).
'hiding' indicates putting letters inside.
'south american' becomes 'sus' (I've seen this in other clues).
'die' enclosing 'sus' is 'DISUSE'.
(Other definitions for disuse that I've seen before include "Fall into this state to be unemplyed? (6)." , "State of not being employed" , "Issued (anag)" , "Neglect; desuetude" , "Neglect; abandonment" .)