Strange new Roman lab (8)
I believe the answer is:
abnormal
'strange' is the definition.
(both can mean unusual)
'new roman lab' is the wordplay.
'new' indicates anagramming the letters.
'roman'+'lab'='romanlab'
'romanlab' anagrammed gives 'ABNORMAL'.
(Other definitions for abnormal that I've seen before include "Quite unusual" , "Freakish" , "The reverse of 32 Across" , "Highly unusual" , "Deviant or unnatural" .)