Crossword Genius

Strange to hold medical procedure where waste emerges (6)

Ross

I believe the answer is:

rectum

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'where waste emerges' is the definition.
Although both the answer and definition are singular nouns, I can't see how they can define each other.

'strange to hold medical procedure' is the wordplay.
'strange' becomes 'rum' (similar in meaning).
'to hold' means one lot of letters goes inside another.
'medical procedure' becomes 'ect' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'rum' going around 'ect' is 'RECTUM'.

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I've seen this clue in The Guardian.
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