Strife as Red meeting breaks up (12)
I believe the answer is:
disagreement
'strife' is the definition.
(thesaurus)
'as red meeting breaks up' is the wordplay.
'breaks up' indicates an anagram.
'as'+'red'+'meeting'='asredmeeting'
'asredmeeting' is an anagram of 'DISAGREEMENT'.
(Other definitions for disagreement that I've seen before include "dispute" , "Difference of opinion" , "Quarrel" , "Conflict" , "Contretemps" .)