Strong, nevertheless twisted out of line (4)
I believe the answer is:
wiry
'strong' is the definition.
(I've seen this before)
'nevertheless twisted out of line' is the wordplay.
'nevertheless twisted out of' becomes 'wi' (I can't justify this - if you can you should give a lot more credence to this answer).
'line' becomes 'ry' (abbreviation for railway).
'wi'+'ry'='WIRY'
Can you help me to learn more?
(Other definitions for wiry that I've seen before include "Slender but strong and agile" , "with coarse hair" , "strong and slim" , "Strong and flexible" , "Lean, tough, sinewy" .)