Struggle with wife’s opinion (4)
I believe the answer is:
view
'opinion' is the definition.
(I know that opinion can be written as view)
'struggle with wife's' is the wordplay.
'struggle' becomes 'vie' (to vie is to struggle or contend with).
'with' is a charade indicator (letters next to each other).
'wife' becomes 'w' (abbreviation).
'vie'+'w'='VIEW'
(Other definitions for view that I've seen before include "Regard" , "Aspect, scene" , "See" , "Opinion; watch" , "Opinion - vista" .)