Study closely, with "over" (4)
I believe the answer is:
pore
'study closely with over' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for pore that I've seen before include "Rope around tiny hole" , "Where sweat appears" , "Sweat gland" , "Small skin orifice; study" , "Skin opening; look closely (over)" .)