Study medicine briefly with a cupola (5)
I believe the answer is:
domed
'a cupola' is the definition.
(I've seen this before)
'study medicine briefly' is the wordplay.
'study' becomes 'do' (to 'do' a subject at university is to study it).
'medicine briefly' becomes 'med' (as in the informal term 'meds'; 'briefly' indicates an abbreviation).
'do'+'med'='DOMED'
'with' is the link.
(Other definitions for domed that I've seen before include "Shaped like rounded roof" , "cupola" , "not flat!" , "with a meniscus" , "Vaulted" .)