Study, with "over" (4)
I believe the answer is:
pore
'study with over' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for pore that I've seen before include "Rope around tiny hole" , "Small skin orifice; study" , "Sweat-gland opening" , "Minute opening in the skin" , "Sweat gland" .)