Stuff in chapter about destiny (5)
I believe the answer is:
cloth
'stuff' is the definition.
(thesaurus)
'chapter about destiny' is the wordplay.
'chapter' becomes 'ch'.
'about' means one lot of letters goes inside another.
'destiny' becomes 'lot' (I've seen this before).
'ch' placed around 'lot' is 'CLOTH'.
'in' is the link.
(Other definitions for cloth that I've seen before include "Woven material" , "Fabric, textile" , "Gingham, say" , "ministers" , "Sails" .)