Stumbles back with one, in the clutches of booze! (6)
I believe the answer is:
spirit
'clutches of booze' is the definition.
'spirit' can be an answer for 'booze' (thesaurus). I'm not certain of the 'clutches of' bit.
'stumbles back with one in the' is the wordplay.
'stumbles' becomes 'trips' ('trip' can be a synonym of 'stumble').
'back' shows that the letters should be reversed in order.
'with one' becomes 'i' (Roman numeral. I am not sure about the 'with' bit.**).
'in the' is an insertion indicator.
'trips' reversed gives 'spirt'.
'spirt' placed around 'i' is 'SPIRIT'.
Can you help me to learn more?
(Other definitions for spirit that I've seen before include "in play with 10 [BLITHE]" , "Mood - ghost - liquor" , "Courage, determination" , "bottle?" , "Ghost or soul" .)